Association of the rs17782313, rs17773430 and rs34114122 Polymorphisms of/near MC4R Gene with Obesity-Related Biomarkers in a Spanish Pediatric Cohort

Obesity is a multifactorial disease whose onset and development are shaped by the individual genetic background. The melanocortin 4 receptor gene (MC4R) involved in regulation of food intake energy expenditure. Some single nucleotide polymorphisms (SNPs) this related to obesity metabolic risk factors. present study was undertaken assess relationship between three polymorphism SNPs, namely, rs17782313, rs17773430 rs34114122, One hundred seventy-eight children with aged 7 16 years were studied determine anthropometric variables biochemical inflammatory parameters. Our results highlight that factors, especially alterations carbohydrate metabolism, rs17782313. presence minor C allele variants (C–C–C) significantly associated measures indicative obesity, such as body mass fat indexes, increased values insulinemia 21.91 µIU/mL respect wild type values. suggests C–C–C haplotype SNPs rs34114122 MC4R potentiates factors at early ages obesity.